Letrozole Drug Description
Letrozole is a medication primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. It falls under the category of aromatase inhibitors, which play a crucial role in reducing estrogen levels in the body, thereby slowing the growth of certain types of breast tumors that rely on estrogen for growth.
Mechanism of Action
The letrozole drug description highlights its primary function as an aromatase inhibitor. Aromatase is an enzyme that converts androgens into estrogens. By inhibiting this enzyme, letrozole effectively lowers circulating estrogen levels, which is essential for managing certain breast cancers.
Indications
- Treatment of hormone receptor-positive early Letrozol Mylan Filmtabletten 2.5mg 100 drug description breast cancer in postmenopausal women.
- Adjuvant therapy after surgery to reduce the risk of cancer recurrence.
- Advanced breast cancer treatment in postmenopausal women who have progressed on other therapies.
Dosage and Administration
Letrozole is typically administered orally. The recommended dosage for adults is:
- Initial Dose: 2.5 mg once daily.
- Duration: Treatment continues until disease progression or unacceptable toxicity occurs.
Side Effects
- Hot flashes
- Joint pain
- Fatigue
- Nausea
- Bone density loss
Contraindications
It is important to consider certain contraindications, such as:
- Hypersensitivity to letrozole or any of its components.
- Pregnancy and breastfeeding.
Drug Interactions
Patients should be aware of potential interactions with other medications, which may alter the effectiveness of letrozole or increase the risk of side effects. Common interacting drugs include:
- Estrogen-containing therapies
- Anticonvulsants
- Certain antidepressants
FAQs about Letrozole
1. How long does it take to see results from letrozole?
Many patients may begin to notice changes within a few weeks; however, full benefits can take several months.
2. Can letrozole be taken with food?
Yes, letrozole can be taken with or without food, but consistency is key for optimal results.
3. What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses.
Conclusion
The letrozole drug description emphasizes its vital role in the management of estrogen-dependent breast cancer in postmenopausal women. As with any medication, understanding its uses, side effects, and interactions is crucial for maximizing its therapeutic benefits while minimizing risks.